Product Info Summary
SKU: | A00977 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-Myocilin MYOC Antibody
SKU/Catalog Number
A00977
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Myocilin MYOC Antibody catalog # A00977. Tested in WB applications. This antibody reacts with Human,Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Myocilin MYOC Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00977)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human LRP6 protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A00977 is reactive to MYOC in Human, Mouse
Applications
A00977 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
56.972kDa
Background of Myocilin
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Gingras AC, et al. (1998) Genes Dev 12(4): 502-513.
Brugarolas J, et al. (2004) Genes Dev 18(23): 2893-2904.
Kumar V, et al. (2000) EMBO J 19(5): 1087-1097.
Moody CA, et al. (2005) J Virol 79(9): 5499-5506.
Burnett PE, et al. (1998) Proc Natl Acad Sci U S A 95(4): 1432-1437.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-Myocilin MYOC Antibody A00977
Western blot analysis of extracts of human heart tissueProtein Target Info & Infographic
Gene/Protein Information For MYOC (Source: Uniprot.org, NCBI)
Gene Name
MYOC
Full Name
Myocilin
Weight
56.972kDa
Alternative Names
GLC1A; GLC1Amyocilin; GPOA; JOAG; JOAG1; MYOC; Myocilin; myocilin, trabecular meshwork inducible glucocorticoid response; TIGR; TIGRmutated trabecular meshwork-induced glucocorticoid response protein; Trabecular meshwork-induced glucocorticoid response protein MYOC GLC1A, GPOA, JOAG, JOAG1, TIGR myocilin myocilin|juvenile-onset open-angle glaucoma 1|mutated trabecular meshwork-induced glucocorticoid response protein|myocilin 55 kDa subunit|myocilin trabecular meshwork inducible glucocorticoid response protein|trabecular meshwork inducible glucocorticoid response protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MYOC, check out the MYOC Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MYOC: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Myocilin MYOC Antibody (A00977)
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No publications found for A00977
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Customer Reviews
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